BioPure’s CORE-S is a modified formulation of our CORE product. CORE-S provides highly bioavailable forms of 6 minerals, 4 vitamins, 1 amino acid, and an herb, in a unique combination formulated to support core aspects of human health.
With the exception of calcium, that forms a major part of our bone structure, most of the minerals in the human body are present in relatively small amounts, but their importance to human health cannot be overstated. The trace minerals in CORE-S play critical roles as cofactors in a myriad of enzymatic pathways. Although most minerals are available in foods we eat, deficiencies can occur from a number of causes including environmental factors, injury recovery, genetics, stress, medications, overexertion, athletes demanding high performance, aging, diets, bacterial infections, and lifestyle differences [Huskisson et al 2007; Soetan et al 2010]. CORE-S provides an additional source of important trace minerals and other nutrients.
In CORE-S, we have removed supplemental manganese from the formula for consumers who may prefer this formulation based on their consultation with their health care provider. It is important to understand that manganese is an essential trace mineral that plays critical roles in the skeletal, circulatory, reproductive, and nervous systems, and numerous enzymatic, immune, and antioxidant reactions throughout the body [Aschner and Aschner 2005]. Even though most people receive sufficient amounts from the food they eat (especially manganese-rich foods such as pineapple, pecans, peanuts, oats, wheat, and beans), we suggest consulting your healthcare practitioner to be sure you are receiving an adequate supply of manganese in your diet.
CORE-S contains the following:
Vitamin A (700 iu): Vitamin A comprises a group of fat-soluble retinoids especially important for eyesight, reproduction, immune function, skin health, and cellular transport reactions [nih/Vitamin A website].
B6, in the form of Pyridoxine HCl (20 mg) and Pyridoxine 5-Phosphate (33.5 mg): These compounds provide bioactive B6, readily available to participate as a cofactor in nearly 100 enzymatic reactions within the human body. One of eight water-soluble vitamins in the B complex, B6 is critical in the production of amino acids, in obtaining energy from the food we eat [Huskisson et al 2007], and in contributing a protective effect on the heart [Suidasari et al 2015].
Biotin (3,000 mcg): Biotin is a member of the B complex and is sometimes referred to as Vitamin H. It is an essential micronutrient for all mammals [Said 2002]. As a coenzyme, Biotin plays key roles in the breakdown of fats, carbohydrates, and proteins [Rodriguez 2000]. It supports skin, hair, and nail health, blood sugar metabolism, and proper neurological function [Said 2002], and is particularly important during pregnancy for proper fetal development [Mock 2014].
Niacin (20 mg): Also referred to as B3, niacin is another one of the 8 vitamins in the B complex. Niacin is perhaps best known for its support of healthy cholesterol levels [Shobha et al 2003]. Like B6, niacin is also involved in the production of energy from the foods we eat. Niacin also helps the adrenal gland make sex and stress-related hormones.
Magnesium (100 mg): Magnesium is one of the most plentiful minerals in the human body, playing key roles in hundreds of enzymatic reactions and metabolic functions. It helps regulate cell membrane transport, supports healthy bones and teeth, facilitates muscle contraction and normal heart rhythm, relaxes blood vessels, aids in energy production, is part of DNA and RNA synthesis, and more [nih/magnesium website]. Chelated to the amino acid glycine, magnesium bisglycinate in CORE–S provides the highest level of absorption, bioavailability, and safety. The chelated form also creates a buffering effect and may reduce potential laxative side-effects [Seibrecht 2013].
Zinc, as PepZin GI® Carnosine (28.5 mg): Zinc is an essential trace mineral, and is ubiquitous within cells throughout the body. Its numerous roles in human metabolism include catalytic, structural, and regulatory functions [Roohani et al 2013]. Zinc supports the immune system, eyesight, neurological function, and growth and development at all ages– especially prenatally and during infancy [Roohani et al 2013; Prasad 2013]. CORE-S provides zinc in a combined form with the protein-building block carnosine, giving it added value for gastric health. The compound supports maintenance of a healthy mucosal lining in the gut [Mahmood et al 2007].
Chromium (125 mcg): Chromium interacts with thyroid metabolism and plays a major role in the production of insulin and regulation of proper blood glucose levels. It is also involved in RNA synthesis and protein metabolism [Krejpcio 2001; Cefalu and Hu 2004]. Some studies have shown it significantly lowers total and LDL cholesterol [Lamson and Plaza 2002]. The chromium in CORE-S is chemically bound with a form of niacin, known as nicotinate, and the amino acid glycine. Chromium nicotinate glycinate is safe and highly bioavailable.
Molybdenum (50 mcg): Molybdenum is needed in the human body in small amounts to form compounds with organic molecules and enzymes that affect numerous processes including protein synthesis, iron uptake, detoxification, and elimination of wastes. Some people use molybdenum to help resist Candida infections [Miroff et al 1991], to lessen allergic reactions to sulfites [Coughlan 1983], support dental health and cancer therapies. In CORE-S, molybdenum is bound to the amino acid glycine, facilitating its absorption and bioavailablity.
Boron as citrate chelate (750 mcg): Although not yet considered essential, there is growing evidence of the importance of this trace mineral [Dinca & Scorei 2013; Nielsen & Meacham 2011]. Boron is involved in many bodily functions including the metabolism of calcium, magnesium, and vitamin D, supporting healthy bone growth and joint movement, and in the regulation of thyroid and sex hormones. Boron may also be helpful to people suffering with arthritis, and may assist in the prevention of osteoarthritis and osteoporosis [Newnham 1994; Nielsen & Meacham 2011].
L-Taurine (50 mg): Taurine is an amino acid, important for heart function, vasodilation, and as an antioxidant [Xu et al 2008]. Taurine also supports healthy gallbladder function, metabolism of cholesterol and bile, and retinal development and function [Lourenço & Camilo 2002].
Lithium (3 mg): Lithium is a metal that is found within many minerals. In the orotate chelate compound, it is available to the human body in a safe, low-dose, highly absorbable form. Lithium affects the flow of sodium through our muscle and nerve cells [drugs.com]. It supports B12 and folate metabolism, has antioxidant and anti-inflammatory properties, and has shown strong neuroprotective [Marshall 2015] and mood-stabilizing potential [Cipriani et al 2013].
Horsetail (2 mg): The herb, horsetail (Equisetum arvense), has been used in herbal medicine since ancient Roman and Greek times. It is especially known for its diuretic and beneficial effects on the kidneys and bladder. Other uses have included controlling bleeding, and supporting the body in healing wounds, ulcers, and tuberculosis. In addition, it has shown antioxidant, anti-inflammatory, and mood-stabilizing properties [Bahmani et al 2015].
Other ingredients present in small amounts are silica, cellulose, and ascorbyl palmitate. Silica, also known as silicon dioxide, is a naturally occurring substance that the human body needs a very small amount of for healthy bones, collagen, and cartilage [Martin 2007]. In CORE-STM, silica serves the dual purpose of acting as a flow agent in supplements. The capsules are made with a small amount of non-digestible cellulose, providing a vegetarian alternative to animal-sourced gelatin capsules. Ascorbyl palmitate is a fat-soluble antioxidant that contributes an insignificant amount of Vitamin C, and primarily serves the purpose of protecting and extending the shelf-life of all the fat-soluble antioxidants in the supplement [Pokorski et al 2003].