BioPure’s Czaga (pronounced ‘chaga’) is made from the fungus, Inonotus Obliquus. This mushroom grows as an irregularly formed mass of mycelium, resembling burnt charcoal, on the bark of birch trees in Siberia, Russia, eastern Europe, and some parts of the United States and Canada. Chaga has been revered as a medicinal substance for centuries (Mu 2012). The most common way it was used traditionally was to boil it and create an aqueous extract. It was considered a cleansing and disinfecting substance (Lemieszek 2011) and was used internally and externally as a remedy for bacterial, viral, fungal, and parasitic infections, and to help heal injuries and rashes. It was also commonly used for treating diabetes, hypertension, stomach ulcers, and other gastric disorders.
Chaga mushrooms have been found to contain a wide variety of biologically active compounds and secondary metabolites (Zheng 2010) including triterpenoids such as inotodiol, lanosterol, and betulinic acid, sterols such as ergosterol; melanins, phenolic compounds, polysaccharides, vitamins, proteins, and more.
Numerous studies have been carried out with Chaga extracts and components. The melanin complex of Chaga is believed to exert genoprotective effects (Bisko 2002). Cognitive functions, such as learning and memory in mice were enhanced in response to treatment with an extract of Chaga (Giridharan 2011). DNA damage and fragmentation was reduced in lymphocytes of humans with inflammatory bowel disease (Najafzadeh 2007). Restorative effects on pancreatic tissue of diabetic mice suggests Chaga’s antioxidant and antihyperglycemic effects (Sun 2008). An aqueous extract of Chaga reduced nasal inflammation and significantly inhibited membrane fusion of Herpes simplex virus (Pan 2013). Chaga’s polysaccharides have been found to promote macrophage scavenging activity, stimulate immune responses, and have significant antioxidant activity (Kim 2005, Won 2011, Cui 2005, Zheng 2011, Mu 2012).
The processes of aging, inflammation, and susceptibility to various diseases, have all been related to free-radical induced damage at the cellular level (Gemma 2007). Oxidative stress is also indicated in the growth of many cancers and Chaga has stimulated numerous studies in this area. Betulinic acid inhibited growth in human melanoma cells by inducing apoptosis (Mullauer 2010, Fulda 2008). Hot water extract of Chaga mushroom similarly suppressed the proliferation of human colon cancer cells (Lee 2009). Inotodiol showed an antiproliferative effect in mouse leukemia cells (Nomura 2008). The fact that Chaga produced little or no toxicity in any of its experiments makes it well-deserving of further study for its promising anti-cancer therapies and other health benefits (Lemieszek 2011).
BioPure’s Czaga is a freeze-dried extract of 100 percent organic wild Inonotus Obliquus, and is not produced from cultivated sources. It is sustainably harvested from fungi growing on wild live birch trees in severe northern climates. This maximizes the availability and potency of the beneficial bioactive ingredients. BioPure’s Czaga™ makes a delicious vanilla flavored beverage. Some people use is as a substitute for coffee.
- Provides antioxidant protection*
- Supports a healthy immune system*
- Supports the body’s natural processes of microbial, fungal and parasitic defense*
- Supports healthy liver function*
- Supports a healthy cardiovascular system*
- Maintains healthy blood sugar metabolism*
- Supports a healthy nervous system response*
3 grams (approximatley one teaspoon)
Servings per Container: 33 servings
Directions: Mix 3 grams of Czaga extract in warm or cold water. Drink twice daily with meals or as directed by your practitioner.
NOTE: The current label on the Czaga is incorrect. The correct serving size, servings per container and directions are as listed above.
Chaga (whole Mushroom), 1000mg*
Bisko, NA, Mitropolskaya NY, Ikonnikova NV. Melanin Complex from Medicinal Mushroom Inonotus obliquus (Pers.: Fr.) Pilat (Chaga) (Aphyllophoromycetideae). Int J Med Mushrooms. 2002, Vol 4, Issue 2.
Cui Y, Kim DS, Park KC. Antioxidant effect of Inonotus obliquus. J Ethnopharmacol. 2005 Jan 4;96(1-2):79-85.
Fulda S. Betulinic Acid for Cancer Treatment and Prevention. Int J Mol Sci. 2008 June; 9(6): 1096–1107.
Gemma C, Vila J, Bachstetter A, Bickford PC. Oxidative Stress and the Aging Brain: From Theory to Prevention. Chapter 15. In: Brain Aging – Models, Methods, and Mechanics. Edited by David R Riddle. CRC Press 2007.
Giridharan VV, Thandavarayan RA, Konishi T. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress byInonotus obliquus – a medicinal mushroom. Food Funct. 2011 Jun;2(6):320-7.
Kim YO, Han SB, Lee HW, Ahn HJ, Yoon YD, Jung JK, Kim HM, Shin CS. Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus. Life Sci. 2005 Sep 23;77(19):2438-56.
Lee SH, Hwang HS, Yun JW. Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. Phytotherapy Research. Volume 23, Issue 12, pages 1784–1789, December 2009.
Lemieszek MK, Langner E, Kaczor J, Kandefer-Szerszeń M, Sanecka B, Mazurkiewicz W, Rzeski W. Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies. Int J Med Mushrooms. 2011;13(2):131-43.
Mu H, Zhang A, Zhang W, Cui G, Wang S, and Duan J. Antioxidative Properties of Crude Polysaccharides from Inonotus obliquus. Int. J. Mol. Sci. 2012, 13, 9194-9206.
Mullauer FB, Kessler JH, Medema JP. Betulinic acid, a natural compound with potent anticancer effects. Anticancer Drugs. 2010 Mar;21(3):215-27.
Najafzadeh M, Reynolds PD, Baumgartner A, Jerwood D, Anderson D. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease. Biofactors. 2007;31(3-4):191-200.
Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S. Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res. 2008 Sep-Oct;28(5A):2691-6.
Pan HH, Yu XT, Li T, Wu HL, Jiao CW, Cai MH, Li XM, Xie YZ, Wang Y, Peng T. Aqueous extract from a Chaga medicinal mushroom,Inonotus obliquus (higher Basidiomycetes), prevents herpes simplex virus entry through inhibition of viral-induced membrane fusion.Int J Med Mushrooms. 2013;15(1):29-38.
Sun JE, Ao ZH, Lu ZM, Xu HY, Zhang XM, Dou WF, Xu ZH. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol. 2008 Jun 19;118(1):7-13.
Won DP, Lee JS, Kwon DS, Lee KE, Shin WC, Hong EK. Immunostimulating activity by polysaccharides isolated from fruiting body ofInonotus obliquus. Molecules and Cells. February 2011, Volume 31, Issue 2, pp 165-173.
Zheng W, Miao K, Liu Y, Zhao Y, Zhang M, Pan S, Dai Y. Chemical diversity of biologically active metabolites in the sclerotia ofInonotus obliquus and submerged culture strategies for up-regulating their production. Appl Microbiol Biotechnol. 2010 Jul;87(4):1237-54.
Zheng W, Zhang M, Zhao Y, Miao K, Pan S, Cao F, Dai Y. Analysis of antioxidant metabolites by solvent extraction from sclerotia ofInonotus obliquus (Chaga). Phytochem Anal. 2011 Mar-Apr;22(2):95-102.
† or use as directed by your healthcare practitioner.
* Our products are not intended to diagnose, treat, cure or prevent any disease and are designed to be used as part of an overall health plan with your authorized healthcare provider. Individuals taking food supplements or have an underlying health condition should consult with their authorized healthcare provider before using these products. We suggest that you consult your authorized healthcare provider if you have any health problems and require a medical diagnosis, medical advice or treatment. Statements herein have not been evaluated by the FDA. We do not recommend any of our natural products to be used for small children without the guidance of a licensed healthcare provider. We do not recommend that any of our products be used while breastfeeding, while pregnant or trying to become pregnant.
** Allergy test by using trace amount on skin and observing for 24 hours. Continue allergy test for consumption with trace amount and observe for 24 hours. Stop use of product if adverse reactions occur with ongoing use.