BioPure LipoSorb Liposomal Phospholipid

Price:$ 75.00

LipoWell and LipoSorb

Each teaspoon-sized serving BioPure’s LipoWell and LipoSorb provides 700 mg of a critically important lipid known as phosphatidylcholine. The difference between the two products is that LipoWell is derived from purified sunflower, while LipoSorb is derived from purified soy. BioPure has developed these two different formulas to accommodate the sensitivities of some of our customers.

Product Description

LipoWell and LipoSorb

Each teaspoon-sized serving BioPure’s LipoWell and LipoSorb provides 700 mg of a critically important lipid known as phosphatidylcholine. The difference between the two products is that LipoWell is derived from purified sunflower, while LipoSorb is derived from purified soy. BioPure has developed these two different formulas to accommodate the sensitivities of some of our customers.

The term “phosphatidylcholine” is often used synonymously with “lecithin”, although the two are not exactly the same. Lecithin is actually a more generic term for a combination of phospholipids, the primary one being phosphatidylcholine. Foods such as egg yolks, soybeans, beef, liver, fish, pork, sunflower, and canola, are rich in lecithin and represent some of the natural dietary sources of phosphatidylcholine (DRI 2006-Choline). Lecithin is also produced commercially and is commonly added to foods as an emulsifier or sold as a supplement. Phosphatidylcholine may comprise anywhere from 20% to 90% of commercially prepared lecithins (LPI-Choline).

Structurally speaking, phosphatidylcholine is in a class of chemical compounds known as phospholipids, composed of a choline head group, glycerophosphoric acid, and two fatty acids (AOCS Library, Wikipedia). Phosphatidylcholine is one of the most important, and the most abundant phospholipids present in the human body (AOCS Library, Kanna et al. 2007). It has both hydrophilic and hydrophobic properties, making it a perfect and structural component of cellular membranes, and allowing it to play critical roles in cell membrane interactions such as messaging and transport of substances across the cell wall.

Phosphatidylcholine has a particularly prominent presence in the extensive cell membrane surfaces of the liver, where it has been shown to aid in repairing damage from toxins, metals, pharmaceuticals, alcohol, and viruses (Kidd 1996). It is also involved in hepatic export of very low-density lipoproteins, which are important in preventing fatty liver disease (LPI-Choline), and in supporting healthy cholesterol metabolism (Olthof et al. 2005). The liver is intricately involved in phosphatidylcholine homeostasis, serving to receive, recycle, and remanufacture phosphatidylcholine and other needed lipoproteins (Li et al. 2005, Vance 2008).

Phosphatidylcholine breakdown supports the body’s supply of choline, and vice versa. Choline is an essential nutrient involved in most of the same functions as phosphatidylcholine. Choline is critical to normal fetal development and healthy metabolism in adults (Zeisel 2006, Zeisel and da Costa 2009). It was once believed that the human body was able to manufacture enough choline on its own, but research has shown that supplementation, in the form of phosphatidylcholine, is beneficial (Olthoff et al. 2005), and may even enhance performance in sports (Jäger 2007). Choline is a precursor molecule to the important neurotransmitter, acetylcholine, essential to proper nervous system functioning throughout the body, including muscle control, brain activity, and memory (Taylor and Brown 1999, Zeisel and da Costa 2009). Folate and methionine are also critical to cognitive health (Troen et al. 2008). Choline, folate, and methionine have all been identified as essential dietary substances by the National Academy of Sciences, Institute of Medicine (DRI 2006). Phosphatidylcholine is closely involved in maintaining equilibrium and an adequate supply of each of these important substances in the human body (Troen et al. 2008, Jacob et al. 1999, Ziesel 1994). If the metabolism of one is disturbed, it directly affects the metabolism of the others. In this way, phosphatidylcholine plays an integral role in supporting the body’s resistance to cognitive decline and disorders such as dementia and Alzheimers (Whiley et al. 2009, Blusztajn et al. 1987, Troen et al. 2008).

The anti-inflammatory properties of phosphatidylcholine indicate potential to aid in the management of disorders such as ulcerative colitis (Treede et al. 2007) and arthritis (Hartmann et al. 2009). It appears to also be important during pregnancy for proper  development of the fetal immune system (Lewis et al. 2013). Phosphatidylcholine is also present throughout organelles within the cell and plays roles in beneficial types of apoptosis (Wright et al. 2004).

The phosphatidylcholine in both LipoWell and LipoSorb is arranged in micelles. These are a type of nanosized, single-layered vesicular structures in which the hydrophilic heads of the phosphatidylcholine molecules congregate on the outer surface and the hydrophobic tails all face toward the center of the vesicle. Arrangement in micelles allows the oil-soluble phospholipid to become easily absorbed in the watery environment of the small intestine, increasing bioavailability and efficacy (Maher 2008).

D-α-tocopheryl polyethylene glycol succinate, or vitamin E TPGS is a water-soluble form of vitamin E. It is FDA-approved as a nutritional supplement and a drug delivery vehicle and is listed as a GRAS (Generally Regarded As Safe) substance (Yan et al. 2007). TPGS is also considered safe by the European Food Safety Authority (EFSA 2007). The presence of TPGS in these formulations provides many benefits, including enhancing the cellular uptake of the phosphatidylcholine, stabilizing the micelles (Guo et al. 2013), sustaining the release time (Yan et al. 2007, Zhang et al.2012), and providing a small source of the antioxidant vitamin E.

References:

Blusztajn JK, Liscovitch M, Mauron C, Richardson UI, Wurtman RJ. Phosphatidylcholine as a precursor of choline for acetylcholine synthesis. J Neural Transm Suppl. 1987:24:247-59.

Dietary Reference Intakes: The Essential Guide to Nutrient Requirements (2006) http://www.nap.edu/catalog/11537.html

EFSA Journal (2007) 490, 1-20. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in use for food for particular nutritional purposes.

Guo Y, Luo J, Tan S, Otieno BO, Zhang Z. The applications of Vitamin E TPGS in drug delivery. European Journal of Pharmaceutical Sciences 49 (2013) 175-186.

Hartmann P, Szabó A, Erős G, Gurabi D, Horváth G, Németh I, Ghyczy M, Boros M. Anti-inflammatory effects of phosphatidylcholine in neutrophil leukocyte-dependent acute arthritis in rats. European Journal of Pharmacology. Volume 622, Issues 1–3, 10 November 2009, Pages 58–64.

http://en.wikipedia.org/wiki/Phosphatidylcholine

http://lipidlibrary.aocs.org/Lipids/pc/index.htm

http://lpi.oregonstate.edu/mic/other-nutrients/choline

Jacob RA, Jenden DJ, Allman-Farinelli MA, Swendseid ME. Folate nutriture alters choline status of women and men fed low choline diets. J Nutr. 1999 Mar;129(3):712-7.

Jäger R, Purpura M, and Kingsley M. Phospholipids and sports performance. J Int Soc Sports Nutr. 2007; 4: 5.

Kanna

Kidd PM, Ph.D. Phosphatidylcholine: A Superior Protectant Against Liver Damage. Alternative Medicine Review. 1996. Volume 1, Number 4: 258-274.

Lewis ED, Goruk S, Curtis JM, Jacobs RL, and Field CJ. Supplementation with phosphatidylcholine during suckling improves the immune response of the offspring. The FASEB Journal. April 2013. 27:Meeting Abstract Supplement 123.8.

Li Z, Agellon LB, Vance DE. Phosphatidylcholine homeostasis and liver failure. J Biol Chem. 2005 Nov 11;280(45):37798-802.

Maher J. Liposomes and Micelles. Mother Nature’s Natural Nanotechnology. Dynamic Chiropractic. June 17, 2008, Vol. 26, Issue 13.

Olthof MR, Brink EJ, Katan MB, and Verhoef P. Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men. Am J Clin Nutr. July 2005, vol. 82 no. 1:111-117.

Taylor P and Brown JH. Synthesis, Storage and Release of Acetylcholine. In: Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 6th edition. Siegel GJ, Agranoff BW, Albers RW, et al., editors. Philadelphia: Lippincott-Raven; 1999.

Treede I, Braun A, Sparla R, Kühnel M, Giese T, Turner JR, Anes E, Kulaksiz H, Füllekrug J, Stremmel W, Griffiths G, Ehehalt R.. Anti-inflammatory effects of phosphatidylcholine. J Biol Chem. 2007 Sep 14;282(37):27155-64.

Troen AM, Chao WH, Crivello NA, D’Anci KE, Shukitt-Hale B, Smith DE, Selhub J, Rosenberg IH. Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine. J Nutr. 2008 Dec;138(12):2502-9.

Vance DE. Role of phosphatidylcholine biosynthesis in the regulation of lipoprotein homeostasis. Curr Opin Lipidol. 2008 Jun;19(3):229-34.

Whiley L, Sen A, Heaton J, Proitsi P, García-Gómez D, Leung R, Smith N, Thambisetty M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S, Legido-Quigley C; AddNeuroMed Consortium. Evidence of altered phosphatidylcholine metabolism in Alzheimer’s disease. Neurobiol Aging. 2014 Feb;35(2):271-8.

Wright MM, Howe AG, Zaremberg V. Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues. Biochem Cell Biol. 2004 Feb;82(1):18-26.

Yan A, Von Dem Bussche A, Kane AB, Hurt RH. Tocopheryl Polyethylene Glycol Succinate as a Safe, Antioxidant Surfactant for Processing Carbon Nanotubes and Fullerenes. Carbon N Y. 2007 Nov;45(13):2463-2470.

Zeisel SH and da Costa KA. Choline: An Essential Nutrient for Public Health. Nutr Rev. 2009 Nov; 67(11): 615–623.

Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr. 2006;26:229-50.

Zeisel SH. Choline: Human Requirements and Effects on Human Performance. In: Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Washington (DC): National Academies Press (US); 1994.

Zhang Z, Tan S, and Feng SS. Vitamin E TPGS as a molecular biomaterial for drug delivery. Biomaterials. 2012 Jun;33(19):4889-906.

† or use as directed by your healthcare practitioner.

* Our products are not intended to diagnose, treat, cure or prevent any disease and are designed to be used as part of an overall health plan with your authorized healthcare provider. Individuals taking food supplements or have an underlying health condition should consult with their authorized healthcare provider before using these products. We suggest that you consult your authorized healthcare provider if you have any health problems and require a medical diagnosis, medical advice or treatment. Statements herein have not been evaluated by the FDA. We do not recommend any of our natural products to be used for small children without the guidance of a licensed healthcare provider. We do not recommend that any of our products be used while breastfeeding, while pregnant or trying to become pregnant.

** Allergy test by using trace amount on skin and observing for 24 hours. Continue allergy test for consumption with trace amount and observe for 24 hours. Stop use of product if adverse reactions occur with ongoing use.